Their showdown comes with the highest stakes for a vice presidential debate in recent memory, in part because President Donald Trump's coronavirus diagnosis has made it unclear if and how additional presidential debates will take place.

It will also mark a historic moment, as Sen. Harris of California becomes the first Black and South Asian woman to participate in a general election presidential campaign debate. 

The 90-minute debate will take place at 8 am Hanoi time (1 am UTC) at the University of Utah's Kingsbury Hall in Salt Lake City.

Susan Page, USA Today's Washington bureau chief, will moderate. Page has covered six presidential administrations and 10 presidential elections.