The new cases include 35 in Bac Giang, 12 in Bac Ninh, and 1 in Da Nang, according to the Ministry of Health.
The 2 imported infections have been quarantined in the southern province of An Giang, raising the overall number of imported cases to 1,509.
Vietnam has so far confirmed 6,166 locally-transmitted cases, including 4,596 since the fourth coronavirus wave hit the country in late April.
On Wednesday, Vietnam recorded the 49th death related to COVID-19, which is the first death in HCM City.
According to the Ho Chi Minh City Hospital for Tropical Diseases, the 37-year-old female patient died of severe COVID-19 disease, shock, infection, heart failure on the basis of hypertension, and end-stage chronic kidney disease.