Kirstie Alley arrives at the house as the reality show 'Celebrity Big Brother' starts, in Elstree, near London, Britain August 16, 2018. (REUTERS/Henry Nicholls)

Alley's breakout role came as Rebecca Howe in the NBC sitcom "Cheers", which she starred in from 1987 until 1993, and for which she received an Emmy and a Golden Globe award in 1991. She won her second Emmy in 1994 for the television film "David's Mother."

Alley also starred alongside John Travolta in the 1989 film comedy "Look Who's Talking" and its two sequels.

"Kirstie was one of the most special relationships I’ve ever had," Travolta said on Instagram alongside a photo of the actress in a white dress. "I love you Kirstie. I know we will see each other again."

Alley starred as the title character in the sitcom "Veronica's Closet" from 1997 to 2000, earning Golden Globe and Emmy nominations.

She later competed on "Dancing with the Stars" and "The Masked Singer."