The move is part of an effort to boost vaccinations as the state prepares to fully reopen its economy on June 15.
Ten Californians who become inoculated before that date stand to win lottery-style prizes of 1.5 million USD apiece, while another 30 people will each win 50,000 USD.
Beginning Thursday, the first two million Californians to become vaccinated will each win 50 USD gift cards for cash or groceries, the state said.