Blinken, on his second trip to Israel in a month, is due to discuss with Prime Minister Benjamin Netanyahu and other Israeli leaders concrete steps to minimise harm to civilians in besieged Gaza, where food, fuel, water and medicine are scarce.
The White House, meanwhile, said any pauses in fighting should be temporary and localised, and insisted they would not stop Israel defending itself.
The Israel Defense Forces, in a statement on Friday, said its jets, artillery and navy had struck Hamas targets overnight, killing several militants including Mustafa Dalul, a Hamas commander it said had directed combat in the Gaza Strip.